Autoimmune hemolytic anemia
Education on Autoimmune hemolytic anemia and Alpha-1 Antitrypsin research from the Mark Egly Foundation, with claims from the patent-pending application clearly labeled as hypothesis.
Research status: Investigational / hypothesis
Research hypothesis, not medical advice
The connections described on this page come from Mark Egly's patent-pending application US20220160847A1 (Appl. No. 17/527,730) and ongoing research. They are not established medical facts. Always work with your physician for diagnosis and treatment.
Research hypothesis. The connection between Autoimmune hemolytic anemia and Alpha-1 Antitrypsin is described in Mark Egly's patent-pending application. This is not established medical fact and is not medical advice. Always talk with your doctor about your own health.
What is Autoimmune hemolytic anemia?
Autoimmune hemolytic anemia is a health condition discussed in Mark Egly's research on Alpha-1 Antitrypsin. Autoimmune conditions involve the immune system attacking the body's own tissues. Mark Egly's patent-pending application links many autoimmune diseases to low Alpha-1 Antitrypsin (AAT) or Alpha-1 Antitrypsin Deficiency (AATD) and excess neutrophil activity.
What Mark Egly's patent-pending application discusses
A large number of autoimmune diseases occur because the body's homeostasis is altered by an overabundance of neutrophils or neutrophil elastase ("NE"). The level of neutrophils in the body can be controlled through administration of or supplementation with AAT. A diagnosis of an autoimmune disease may be indicative of AATD or an insufficient level of AAT without being AATD. By identifying lower or deficient AAT levels improved disease control can be realized through administration of or supplementation with AAT. In addition, patients will experience less inflammation as a result of the administration of, or supplementation with AAT. With reduced inflammation, need for aspirin and similar products to relieve pain will be reduced and potential liver disease and other conditions associated wi
How this may relate to Alpha-1
Mark Egly's patent-pending application proposes that when the body has too little working Alpha-1 Antitrypsin, or when neutrophils release too much neutrophil elastase, inflammation and tissue damage may worsen. For Autoimmune hemolytic anemia, Mark Egly's patent-pending application suggests that testing for AATD or low circulating AAT could help guide care. This is a research hypothesis, not a proven treatment path for everyone with this condition.
What you can do
If you or a family member lives with Autoimmune hemolytic anemia, consider learning about Alpha-1 Antitrypsin Deficiency and discussing AAT testing with your healthcare team. The Mark Egly Foundation offers education and community support:
Sources and references
References checked July 26, 2026
- Alpha-1 antitrypsin deficiency (MedlinePlus Genetics (NIH))Research status: Established clinical knowledge
- American Thoracic Society / European Respiratory Society statements on lung disease (locate current AATD guidance) (American Thoracic Society)Research status: Established clinical knowledgeUse the current ATS/ERS AATD statements applicable to your practice.
- Method of Preventing and/or Treating a Plurality of Diseases — patent pending: published U.S. application US20220160847A1 (Appl. No. 17/527,730) (Google Patents)Research status: Investigational / hypothesis
Educational content only. Not a diagnosis or treatment plan. Work with your clinician for personal medical decisions.