Fibrosis
Education on Fibrosis and Alpha-1 Antitrypsin research from the Mark Egly Foundation, with claims from the patent-pending application clearly labeled as hypothesis.
Research status: Investigational / hypothesis
Research hypothesis, not medical advice
The connections described on this page come from Mark Egly's patent-pending application US20220160847A1 (Appl. No. 17/527,730) and ongoing research. They are not established medical facts. Always work with your physician for diagnosis and treatment.
Research hypothesis. The connection between Fibrosis and Alpha-1 Antitrypsin is described in Mark Egly's patent-pending application. This is not established medical fact and is not medical advice. Always talk with your doctor about your own health.
What is Fibrosis?
Fibrosis is a health condition discussed in Mark Egly's research on Alpha-1 Antitrypsin. Musculoskeletal conditions affect muscles, bones, and connective tissue.
What Mark Egly's patent-pending application discusses
Fibrosis is characterized by the overgrowth, hardening, and/or scarring of various tissues. Fibrosis is attributed to excess deposition of extracellular matrix components including collagen. Fibrosis is the end result of chronic inflammatory reactions induced by a variety of stimuli including persistent infections, autoimmune reactions, allergic responses, chemical insults, radiation, and tissue injury. AAT is a powerful inhibitor of inflammation. Due to the link between AATD and fibrosis, in one embodiment AAT may be used to treat, control, or prevent fibrosis in patients, either with or without known AATD. A diagnosis of fibrosis may prompt a medical provider to test a patient for AATD. Alternatively, a patient diagnosed with fibrosis may seek genetic testing for AATD through an independent genetic testing company such as 23andMe or geneology.com, a pharmaceutical company supplied test kit or other private methods available. A method for treating a patient suffering from fibrosis with AAT begins with the step of determining if the patient is AAT deficient or has lower AAT levels without being AATD. Determining if the patient is AAT deficient or has lower AAT levels without being…
How this may relate to Alpha-1
Mark Egly's patent-pending application proposes that when the body has too little working Alpha-1 Antitrypsin, or when neutrophils release too much neutrophil elastase, inflammation and tissue damage may worsen. For Fibrosis, Mark Egly's patent-pending application suggests that testing for AATD or low circulating AAT could help guide care. This is a research hypothesis, not a proven treatment path for everyone with this condition.
What you can do
If you or a family member lives with Fibrosis, consider learning about Alpha-1 Antitrypsin Deficiency and discussing AAT testing with your healthcare team. The Mark Egly Foundation offers education and community support:
Sources and references
References checked July 26, 2026
- Alpha-1 antitrypsin deficiency (MedlinePlus Genetics (NIH))Research status: Established clinical knowledge
- American Thoracic Society / European Respiratory Society statements on lung disease (locate current AATD guidance) (American Thoracic Society)Research status: Established clinical knowledgeUse the current ATS/ERS AATD statements applicable to your practice.
- Method of Preventing and/or Treating a Plurality of Diseases — patent pending: published U.S. application US20220160847A1 (Appl. No. 17/527,730) (Google Patents)Research status: Investigational / hypothesis
Educational content only. Not a diagnosis or treatment plan. Work with your clinician for personal medical decisions.