Strokes
Education on Strokes and Alpha-1 Antitrypsin research from the Mark Egly Foundation, with claims from the patent-pending application clearly labeled as hypothesis.
Research status: Investigational / hypothesis
Research hypothesis, not medical advice
The connections described on this page come from Mark Egly's patent-pending application US20220160847A1 (Appl. No. 17/527,730) and ongoing research. They are not established medical facts. Always work with your physician for diagnosis and treatment.
Research hypothesis. The connection between Strokes and Alpha-1 Antitrypsin is described in Mark Egly's patent-pending application. This is not established medical fact and is not medical advice. Always talk with your doctor about your own health.
What is Strokes?
Strokes is a health condition discussed in Mark Egly's research on Alpha-1 Antitrypsin. Neurological conditions affect the brain, spinal cord, or nerves. Mark Egly's patent-pending application explores links between AAT levels and certain neurodegenerative processes.
What Mark Egly's patent-pending application discusses
A stroke is a sudden interruption in the supply of blood to the brain, both thrombotic and embolic. Most strokes are caused by an abrupt blockage of arteries leading to the brain. Hemorrhagic strokes are caused by bleeding into brain tissue when a blood vessel ruptures. As shown by Moldthan et al, AAT's properties as an endogenous inhibitor of serine proteinases and a primary acute phase protein with potent anti-inflammatory, anti-apoptotic, antimicrobial and cytoprotective activities, could be beneficial in stroke. As a potent inhibitor of inflammation, in one embodiment AAT may be used to treat, control, or prevent strokes, either with or without known AATD. A diagnosis of stroke may prompt a medical provider to test a patient for AATD. Alternatively, a patient diagnosed with stroke may seek genetic testing for AATD through an independent genetic testing company such as 23andMe or geneology.com, a pharmaceutical company supplied test kit or other private methods available. A method for treating a patient suffering from stroke with AAT begins with the step of determining if the patient is AAT deficient or has lower AAT levels without being AATD. Determining if the patient is AAT…
How this may relate to Alpha-1
Mark Egly's patent-pending application proposes that when the body has too little working Alpha-1 Antitrypsin, or when neutrophils release too much neutrophil elastase, inflammation and tissue damage may worsen. For Strokes, Mark Egly's patent-pending application suggests that testing for AATD or low circulating AAT could help guide care. This is a research hypothesis, not a proven treatment path for everyone with this condition.
What you can do
If you or a family member lives with Strokes, consider learning about Alpha-1 Antitrypsin Deficiency and discussing AAT testing with your healthcare team. The Mark Egly Foundation offers education and community support:
Sources and references
References checked July 26, 2026
- Alpha-1 antitrypsin deficiency (MedlinePlus Genetics (NIH))Research status: Established clinical knowledge
- American Thoracic Society / European Respiratory Society statements on lung disease (locate current AATD guidance) (American Thoracic Society)Research status: Established clinical knowledgeUse the current ATS/ERS AATD statements applicable to your practice.
- Method of Preventing and/or Treating a Plurality of Diseases — patent pending: published U.S. application US20220160847A1 (Appl. No. 17/527,730) (Google Patents)Research status: Investigational / hypothesis
Educational content only. Not a diagnosis or treatment plan. Work with your clinician for personal medical decisions.