Over the last 30 years, Mark has had three not-at-fault auto accidents; two times, Mark was struck by individuals texting when driving into Mark at high speeds while his vehicles were sitting still. These three accidents resulted in multiple broken bones and injuries in his body. His right knee, right shoulder, head, neck, and back were affected. Over these 30 years, the deterioration of Mark's health status, he was told that the pain was to be attributed and related to car accidents. What is the relevance here? The significance of the unnecessary pain Mark experienced because of uncontrolled inflammation. The lack of the protease inhibitor Alpha1 Antitrypsin caused inflammation to last much longer than necessary. Neutrophils are present to fight bacteria and infection! When neutrophils are just causing inflammation, the neutrophils are just causing extended pain!